In vitro synergistic effects of metergoline and antifungal agents against Candida krusei

Authors

Kai Kang, The Chinese University of Hong Kong
Kin Sing Wong, The Chinese University of Hong Kong
C. Jayampath Seneviratne, The University of Hong Kong
L.P. Samaranayake, The University of Hong Kong
W.P. Fong, The Chinese University of Hong Kong
Wai Kei Paul Tsang, Technological and Higher Education Institute of Hong Kong, Vocational Training CouncilFollow

Staff Page link

Dr TSANG Wai Kei Paul

Document Type

Journal Article

Publication Date

2010

Keywords

Candida krusei, Metergoline, Phospholipase, Synergism

DOI

10.1111/j.1439-0507.2009.01747.x

Abstract

Metergoline, a serotonin receptor antagonist, was evaluated for its antifungal activity against the opportunistic human fungal pathogen Candida krusei by a broth microdilution assay. The minimal inhibitory concentration and minimal fungicidal concentration of metergoline against C. krusei were 4 and 8 μg ml -1 respectively. Significant synergism was found in combination of metergoline with amphotericin B (fractional inhibitory concentration index: 0.375-0.5) by a chequerboard assay. Metergoline also inhibited extracellular phospholipase secretion in a dose-dependent manner, which may be a possible action mechanism of metergoline on C. krusei.

Source Publication

Mycoses

Volume Number

53

Issue Number

6

ISSN

0933-7407

First Page

495

Last Page

499

Recommended Citation

Kang, K.,Wong, K.,Seneviratne, C.,Samaranayake, L.,Fong, W.,& Tsang, W. (2010). In vitro synergistic effects of metergoline and antifungal agents against Candida krusei. Mycoses, 53 (6), 495-499. http://dx.doi.org/10.1111/j.1439-0507.2009.01747.x