Document Type

Journal Article

Publication Date

2024

DOI

10.1039/d4tb00725e

Abstract

In recent decades, orthopedic implants have been widely used as materials to replace human bone

tissue functions. Among these, metal implants play a crucial role. Metals with better chemical stability,

such as stainless steel, titanium alloys, and cobalt–chromium–molybdenum (CoCrMo) alloy, are commonly

used for long-term applications. However, good chemical stability can result in poor tissue

integration between the tissue and the implant, leading to potential inflammation risks. This study

creates hydrogenated CoCrMo (H-CoCrMo) surfaces, which have shown promise as anti-inflammatory

orthopedic implants. Using the electrochemical cathodic hydrogen-charging method, the surface of the

CoCrMo alloy was hydrogenated, resulting in improved biocompatibility, reduced free radicals, and an

anti-inflammatory response. Hydrogen diffusion to a depth of approximately 106 ± 27 nm on the

surface facilitated these effects. This hydrogen-rich surface demonstrated a reduction of 85.2% in free

radicals, enhanced hydrophilicity as evidenced by a decrease in a contact angle from 83.5 ±1.91 to

52.4 ±2.21, and an increase of 11.4% in hydroxyapatite deposition surface coverage. The cell study

results revealed a suppression of osteosarcoma cell activity to 50.8 ±2.9%. Finally, the in vivo test

suggested the promotion of new bone formation and a reduced inflammatory response. These findings

suggest that electrochemical hydrogen charging can effectively modify CoCrMo surfaces, offering a

potential solution for improving orthopedic implant outcomes through anti-inflammatory mechanisms.

Source Publication

Journal of Materials Chemistry B

Volume Number

12

First Page

7814

Last Page

7825

Download
Link to Publisher’s Version

Share

COinS