Title

In vitro synergistic effects of metergoline and antifungal agents against Candida krusei

Document Type

Journal Article

Publication Date

2010

Keywords

Candida krusei, Metergoline, Phospholipase, Synergism

DOI

10.1111/j.1439-0507.2009.01747.x

Abstract

Metergoline, a serotonin receptor antagonist, was evaluated for its antifungal activity against the opportunistic human fungal pathogen Candida krusei by a broth microdilution assay. The minimal inhibitory concentration and minimal fungicidal concentration of metergoline against C. krusei were 4 and 8 μg ml -1 respectively. Significant synergism was found in combination of metergoline with amphotericin B (fractional inhibitory concentration index: 0.375-0.5) by a chequerboard assay. Metergoline also inhibited extracellular phospholipase secretion in a dose-dependent manner, which may be a possible action mechanism of metergoline on C. krusei.

Source Publication

Mycoses

Volume Number

53

Issue Number

6

ISSN

0933-7407

First Page

495

Last Page

499

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