Title

Caffeine as a photoprotective agent for diminishing phototoxicity

Document Type

Journal Article

Publication Date

2010

Keywords

Phototoxic, Caffeine, 5-MOP, Crosslink, Comet assay

DOI

10.1177/0748233710375947

Abstract

Skin whitening with Chinese herbal medicine has been used in ancient Asia. However, phototoxicity of the active ingredient limits the application. The modified comet assay was used in the current study to detect DNA crosslinking induced by phototoxicity. Result showed that caffeine at 5 µmol/L was able to reduce 5-methoxypsoralen-induced phototoxicity with ultraviolet C (UVC) exposure.

Source Publication

Toxicology and Industrial Health

Volume Number

26

Issue Number

10

ISSN

0748-2337

First Page

667

Last Page

670

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