Comparison of the cytotoxic responses of Escherichia coli (E. coli) AMC 198 to different fullerene suspensions (nC60)

Document Type

Journal Article

Publication Date

2012

Keywords

N C 60, Cytotoxicity, EC 50, Cytoprotection

DOI

10.1016/j.chemosphere.2011.12.024

Abstract

Fullerenes are set to be produced on an industrial scale in anticipation of their wide applications. This calls for research on their environmental and health impacts. This study investigates and compares the cell toxicity of different aqueous fullerene aggregates. Popular C60 dispersal methods were used to prepare four types of nC60 aggregates. These aggregates were tested against the indicator species Escherichia coli (E. coli) AMC 198. With aggregates of around 150nm in diameter, the THF/nC60 suspension was very toxic and gave rise to a half maximal effective concentration (EC50) of 0.54mgL−1 in E. coli. By contrast, the Tol/nC60 suspension exhibited a cytoprotective role while the Aqu-N2/nC60 and Aqu-O2/nC60 suspensions enhanced the metabolism of E. coli. Although some toxicants, such as THF and THF-peroxide, were introduced into the THF/nC60 suspension during the dispersion, the toxicity of nC60 itself cannot be neglected.

Source Publication

Chemosphere

Volume Number

87

Issue Number

4

First Page

362

Last Page

368

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