A phosphorescent rhenium(I) tricarbonyl polypyridine complex appended with a fructose pendant that exhibits photocytotoxicity and enhanced uptake by breast cancer cells

Authors

Kenneth Yin Zhang
Karson Ka Shun Tso
Man Wai Ray Louie, Hong Kong Institute of Vocational Education (Kwai Chung), Vocational Training CouncilFollow
Hua Wei Liu
Kenneth Kam Wing Lo, City University of Hong Kong

Document Type

Journal Article

Publication Date

2013

DOI

10.1021/om400612f

Abstract

We demonstrated that the cytotoxicity of a phosphorescent rhenium(I) polypyridine complex with a fructose pendant was enhanced upon irradiation and the cellular uptake of the complex was mediated by fructose transporters and inhibited by unmodified fructose but was independent of glucose-specific transporters. This complex has been used to image breast cancer cells, where fructose transporters are overexpressed.

Source Publication

Organometallics

Volume Number

32

Issue Number

18

ISSN

0276-7333

First Page

5098

Last Page

5102

Recommended Citation

Zhang, K.,Tso, K.,Louie, M.,Liu, H.,& Lo, K. (2013). A phosphorescent rhenium(I) tricarbonyl polypyridine complex appended with a fructose pendant that exhibits photocytotoxicity and enhanced uptake by breast cancer cells. Organometallics, 32 (18), 5098-5102. http://dx.doi.org/10.1021/om400612f