Construction of a functional assembly of modular enzymes for direct biosynthesis of cephalosporins

Document Type

Conference Proceeding

Publication Date



The worldwide sale of β-lactam antibiotics represents a more than US$20 billion of business per annum. The development of novel β-lactam antibiotics has been a hot issue in the past few decades. Nevertheless, most of them are synthesised via chemical means, whose processing put extensive burden to our environment. 7-Aminocephalosporanic acid (7-ACA) is a key cephem nucleus for a number of semi-synthetic cephalosporins. Conventional chemical synthesis of 7-ACA is environmentally-damaging, and we therefore aim to develop a “greener” approach to synthesise 7-ACA with potential for industrial applications.

Source Publication

THEi 2018 Research Symposium, on 17 May 2018, at the Technological and Higher Education Institute of Hong Kong (THEi)

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