High level expression of secretory phytases in Pichia pastoris

Document Type

Conference Proceeding

Publication Date



Phytases catalyze the release of inorganic phosphate (Pi) from phytate, a major storage compound of phosphorus in plant seeds. However, non-ruminant animals, including humans, swine and poultry, could not digest phytate as they have little phytase activity in their guts. Discharge of undigested phytate into environment may cause phosphorus pollution. Phytate is also considered as an “anti-nutrient” for reducing dietary absorption of essential minerals as it can form insoluble and stable complexes with metal ions such as zinc, iron, magnesium and calcium. It is, therefore, necessary to develop sustainable approaches for environmentally-friendly utilization of this valuable and abundant natural resource. To this end, our team would like to employ baker’s yeast as a tiny factory to produce high level expression of secretory phytases for phytate hydrolysis.

Source Publication

9th International Congress on Biocatalysis, August 2018, Hamburg, Germany

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