Caffeine as a photoprotective agent for diminishing phototoxicity
Phototoxic, Caffeine, 5-MOP, Crosslink, Comet assay
Skin whitening with Chinese herbal medicine has been used in ancient Asia. However, phototoxicity of the active ingredient limits the application. The modified comet assay was used in the current study to detect DNA crosslinking induced by phototoxicity. Result showed that caffeine at 5 µmol/L was able to reduce 5-methoxypsoralen-induced phototoxicity with ultraviolet C (UVC) exposure.
Toxicology and Industrial Health
Szeto, Y.,& Tong, H. (2010). Caffeine as a photoprotective agent for diminishing phototoxicity. Toxicology and Industrial Health, 26 (10), 667-670. http://dx.doi.org/10.1177/0748233710375947