Title

A review of the pharmacological effects of piceatannol on cardiovascular diseases

Document Type

Journal Article

Publication Date

2014

Keywords

Piceatannol, Stilbene, Resveratrol, Cardiovascular diseases

DOI

10.1002/ptr.5185

Abstract

The incidence of cardiovascular diseases (CVDs) is high in both developed and developing countries. It has a high global rate of mortality and causes heavy social burden. Drugs are available for managing or treating CVDs and its complications. Consumption of dietary supplements or functional foods for reducing the risk of CVDs has also gained wide recognition by the general public. Piceatannol, an analog and metabolite of resveratrol, is a natural stilbene commonly found in the skin of grapes and wine. Piceatannol is believed to be a potent compound with certain cardiovascular therapeutic effects, such as the prevention of hypercholesterolemia, arrhythmia, atherosclerosis, and angiogenesis. It also has vasorelaxation and antioxidant activities. A comprehensive review of piceatannol concludes that piceatannol has the potential to be developed into health products for the cardiovascular system to help modern society reduce the high CVD incidence. However, further investigations are warranted in order to increase the bioavailability and understand the biological mechanisms and safety of using piceatannol.

Source Publication

Phytotherapy Research

Volume Number

28

Issue Number

11

First Page

1581

Last Page

1588

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