In vitro synergistic effects of metergoline and antifungal agents against Candida krusei
Candida krusei, Metergoline, Phospholipase, Synergism
Metergoline, a serotonin receptor antagonist, was evaluated for its antifungal activity against the opportunistic human fungal pathogen Candida krusei by a broth microdilution assay. The minimal inhibitory concentration and minimal fungicidal concentration of metergoline against C. krusei were 4 and 8 μg ml -1 respectively. Significant synergism was found in combination of metergoline with amphotericin B (fractional inhibitory concentration index: 0.375-0.5) by a chequerboard assay. Metergoline also inhibited extracellular phospholipase secretion in a dose-dependent manner, which may be a possible action mechanism of metergoline on C. krusei.
Kang, K.,Wong, K.,Seneviratne, C.,Samaranayake, L.,Fong, W.,& Tsang, W. (2010). In vitro synergistic effects of metergoline and antifungal agents against Candida krusei. Mycoses, 53 (6), 495-499. http://dx.doi.org/10.1111/j.1439-0507.2009.01747.x